1 - PVE
I normally just use 1 button combo cuz I'm lazy like that
2 - PVP
Again, on most days, 1 button combo then switch to F1 for lightning slash/blade scud. And yes, that is the dance hotkey, i don't type /dance anymore so i don't /fail.
3 - BM
I retarget with ESC and it's right not top of 1 on my laptop. HP pot is right next to it so I can pot and retarget at the same time.
4 - Buffs
I put the Bike hotkey there when we got the bike lol. Even though i don't usually have the bike, i'm just too lazy to replace it with something like roll lol.